Taguchi F, Kajioka J, Miyamura T
Microbiol Immunol. 1982;26(11):1057-64. doi: 10.1111/j.1348-0421.1982.tb00254.x.
A total of 480 serum samples from donors including 384 children up to 10 years of age were examined by the hemagglutination-inhibition (HI) test for the rates of prevalence and age of acquisition of HI antibodies against JC virus and BK virus. Among 136 serum samples from various age groups, there were five (4%) with no detectable antibodies against BK or JC virus, 75 (55%) with antibodies against both viruses, 41 (30.1%) with antibodies against only BK virus and 26 (19%) with antibodies against only JC virus. The prevalence of antibodies against JC and BK viruses was 70.5% and 80.8%, respectively, and the mean HI titers (4 x 2n,n greater than or equal to 1) were 4.90 and 4.30. About 50% of the children had acquired antibodies against BK virus by 3 years of age and against JC virus by 6 years of age. These results indicate that dual latent infections with both viruses are common, although independent infections with either virus are predominant in the human population.
通过血凝抑制（HI）试验检测了包括384名10岁以下儿童在内的供体的480份血清样本，以了解针对JC病毒和BK病毒的HI抗体的流行率和获得年龄。在来自不同年龄组的136份血清样本中，有5份（4%）未检测到针对BK或JC病毒的抗体，75份（55%）同时具有针对两种病毒的抗体，41份（30.1%）仅具有针对BK病毒的抗体，26份（19%）仅具有针对JC病毒的抗体。针对JC病毒和BK病毒的抗体流行率分别为70.5%和80.8%，平均HI滴度（4×2n，n≥1）分别为4.90和4.30。约50%的儿童在3岁时获得了针对BK病毒的抗体，在6岁时获得了针对JC病毒的抗体。这些结果表明，尽管在人群中以单一病毒的独立感染为主，但两种病毒的双重潜伏感染很常见。
