爱泼斯坦-巴尔病毒启动子附近的同源上游序列。
Homologous upstream sequences near Epstein-Barr virus promoters.
作者信息
Farrell P J, Deininger P L, Bankier A, Barrell B
出版信息
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1565-9. doi: 10.1073/pnas.80.6.1565.
The sequence of the 17,166-base-pair EcoRI C fragment of Epstein-Barr virus DNA, cell line B95-8, was determined. In vitro transcription was used to identify three RNA polymerase II promoters within this fragment of the virus. Cytoplasmic poly(A)+ RNAs starting at these points were demonstrated in B95-8 cells induced into virus production with 12-O-tetradecanoylphorbol 13-acetate. Uninduced B95-8 cells contained much less of these RNAs. The upstream sequences near the three promoters show striking homologies that may be involved in transcriptional control.
测定了爱泼斯坦-巴尔病毒DNA（细胞系B95-8）17,166碱基对EcoRI C片段的序列。利用体外转录来鉴定该病毒片段内的三个RNA聚合酶II启动子。在用12-O-十四烷酰佛波醇-13-乙酸酯诱导产生病毒的B95-8细胞中，证实了从这些位点起始的细胞质多聚腺苷酸（poly(A)+）RNA。未诱导的B95-8细胞中这些RNA的含量要少得多。三个启动子附近的上游序列显示出显著的同源性，这可能与转录调控有关。
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