Johnson R T
Prog Clin Biol Res. 1983;105:183-90.
Polyomaviruses have been implicated in several chronic human neurological diseases. In progressive multifocal leukoencephalopathy there is an opportunistic and lytic infection of oligodendrocytes of the central nervous system leading to subacute demyelinating disease. Although aspects of the pathogenesis remain undefined, the causal role of the viruses seems firm. Nonpermissive infection of neural cells with resultant cerebral tumors has been suggested by epidemiological studies, virus isolations, and detection of viral antigens and nucleic acids. Nevertheless, it is uncertain whether papovaviruses are causally related to human tumors. Possible association of papovavirus infection with other neurological diseases needs further study.
多瘤病毒与几种人类慢性神经疾病有关。在进行性多灶性白质脑病中，中枢神经系统的少突胶质细胞发生机会性和溶解性感染，导致亚急性脱髓鞘疾病。尽管发病机制的某些方面尚不清楚，但病毒的致病作用似乎确凿。流行病学研究、病毒分离以及病毒抗原和核酸的检测表明，神经细胞的非允许性感染会导致脑肿瘤。然而，乳头多瘤空泡病毒是否与人类肿瘤存在因果关系尚不确定。乳头多瘤空泡病毒感染与其他神经疾病的可能关联需要进一步研究。
