Cobb J J, Wickenden C, Snell M E, Hulme B, Malcolm A D, Coleman D V
J Clin Pathol. 1987 Jul;40(7):777-81. doi: 10.1136/jcp.40.7.777.
Urine samples from 50 patients attending a genitourinary outpatient clinic and from 13 renal allograft recipients were investigated for evidence of infection with human BK and JC polyomaviruses using cytology and a new DNA hybridot assay. Forty four per cent of samples from the renal allograft recipients were positive by cytology and 75% by DNA hybridisation, indicating that hybridot assay is more sensitive than cytological screening. BK and JC viral DNA was found in 20% of the patients attending the genitourinary clinic, showing infection with BK virus and JC virus in a group of patients with clinical conditions not normally associated with immunological deficiency-a finding that has not been reported before.
对50名泌尿生殖科门诊患者和13名肾移植受者的尿液样本进行了研究，采用细胞学和一种新的DNA杂交检测法来寻找人类BK和JC多瘤病毒感染的证据。肾移植受者样本中，44%通过细胞学检测呈阳性，75%通过DNA杂交检测呈阳性，这表明杂交检测法比细胞学筛查更敏感。在20%的泌尿生殖科门诊患者中发现了BK和JC病毒DNA，这表明在一组通常与免疫缺陷无关的临床患者中存在BK病毒和JC病毒感染——这一发现此前未见报道。
