丙氨酸-缬氨酸转氨酶在鼠伤寒沙门氏菌中的作用及avtA::Tn5突变体分析
Role of alanine-valine transaminase in Salmonella typhimurium and analysis of an avtA::Tn5 mutant.
作者信息
Berg C M, Whalen W A, Archambault L B
出版信息
J Bacteriol. 1983 Sep;155(3):1009-14. doi: 10.1128/jb.155.3.1009-1014.1983.
Abstract
In Salmonella typhimurium, as in Escherichia coli, mutations in avtA, the gene encoding the alanine-valine transaminase (transaminase C), are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis. avtA is repressed by leucine or alanine but not by valine. Transaminase C is found at reduced levels upon starvation for any one of several amino acids. We hypothesize that this is due to repression of avtA by the elevated alanine and leucine pools found in amino acid-starved cells.
摘要
在鼠伤寒沙门氏菌中，与大肠杆菌一样，编码丙氨酸 - 缬氨酸转氨酶（转氨酶C）的基因avtA中的突变是沉默的，除非它们与参与异亮氨酸 - 缬氨酸生物合成的突变相结合。avtA受亮氨酸或丙氨酸抑制，但不受缬氨酸抑制。在几种氨基酸中的任何一种氨基酸饥饿时，转氨酶C的水平会降低。我们推测这是由于氨基酸饥饿细胞中升高的丙氨酸和亮氨酸池对avtA的抑制作用。
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