大鼠海马中子宫型催产素受体的特性研究
Characterization of a uterine-type oxytocin receptor in the rat hippocampus.
作者信息
Mühlethaler M, Sawyer W H, Manning M M, Dreifuss J J
出版信息
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6713-7. doi: 10.1073/pnas.80.21.6713.
Abstract
Extracellular recordings were obtained from a class of nonpyramidal neurones in hippocampal slices. Oxytocin applied to the bath at concentrations of 1 nM or greater excited these cells. This effect was reversibly antagonized by a synthetic structural analogue known to block the peripheral endocrine effects of oxytocin. The effect of oxytocin was mimicked by a selective oxytocic agonist and, with less potency, by vasopressin and by other structural analogues. The potencies of oxytocin, vasopressin, and of these analogues in the hippocampus correlated well with their uterotonic activities but not with their vasopressor or antidiuretic activities. The data suggest that a class of hippocampal neurones is endowed with receptors for oxytocin that are similar to those of uterine smooth muscle cells.
摘要
从海马切片中的一类非锥体神经元获得了细胞外记录。以1 nM或更高浓度施用于浴槽的催产素使这些细胞兴奋。这种作用被一种已知可阻断催产素外周内分泌作用的合成结构类似物可逆性拮抗。催产素的作用被一种选择性催产激动剂模拟，血管加压素和其他结构类似物的模拟效力较低。催产素、血管加压素及这些类似物在海马中的效力与其子宫收缩活性密切相关，但与其升压或抗利尿活性无关。数据表明，一类海马神经元具有与子宫平滑肌细胞相似的催产素受体。
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