MacLachlan N J, Osburn B I
Vet Pathol. 1983 Sep;20(5):563-73. doi: 10.1177/030098588302000508.
Direct inoculation of bluetongue virus into 125-day bovine fetuses resulted in development of hydranencephaly. The earliest lesions after virus inoculation were a severe necrotizing encephalitis, which was most prominent in the cerebrum, and an associated nonsuppurative meningitis. At birth, the brains of infected fetuses had thin-walled cerebral hemispheres, dilated lateral ventricles, and cerebral cysts. No gross lesions were observed in the brain stem or cerebellum. Two morphologically different lesions were present in the brain of a fetus sacrificed 20 days after virus inoculation. There were discrete foci of hemorrhagic cerebral necrosis that resembled infarcts and widespread microcavitations of the intermediate and subventricular zones. Changes consistent with vascular damage were present in the brains of fetuses sacrificed 12 and 20 days after virus inoculation. Calves with bluetongue virus-induced hydranencephaly would have poor viability, but they would not be expected to have any significance as virus reservoirs.
将蓝舌病毒直接接种到125日龄的牛胎儿体内会导致积水性无脑畸形的发生。病毒接种后最早出现的病变是严重的坏死性脑炎，在大脑中最为明显，以及相关的非化脓性脑膜炎。出生时，受感染胎儿的大脑有薄壁的大脑半球、扩张的侧脑室和脑囊肿。在脑干或小脑中未观察到明显病变。在病毒接种后20天处死的胎儿大脑中存在两种形态不同的病变。有离散的出血性脑坏死灶，类似于梗死灶，以及中间区和脑室下区广泛的微空洞形成。在病毒接种后12天和20天处死的胎儿大脑中存在与血管损伤一致的变化。患有蓝舌病毒诱导的积水性无脑畸形的小牛生存能力较差，但预计它们作为病毒储存宿主没有任何意义。
