Dodson P M, Pacy P J, Beevers M, Bal P, Fletcher R F, Taylor K G
Postgrad Med J. 1983 Oct;59(696):641-4. doi: 10.1136/pgmj.59.696.641.
Fifty-three diabetic patients with mild hypertension were allocated to a treatment diet with a high fibre, low fat and low sodium dietary regime or a control diet. After a 1-month treatment period, the modified-diet treated group (n = 35) showed a highly significant reduction in mean diastolic blood pressure (P less than 0.001) accompanied by significant reduction in urinary sodium excretion (P less than 0.01). The mean values of diastolic pressure (P less than 0.05) and urinary sodium/potassium ratio (P less than 0.01) were also significantly reduced at 1 month compared to control. White (n = 16) and West Indian (n = 10) diabetic hypertensive patients demonstrated a similar significant hypotensive response (P less than 0.05 and less than 0.01 respectively) with reduction in urinary sodium excretion to the modified diet. In contrast, Asian patients demonstrated no significant changes. Treatment of hypertension in diabetic subjects with a high fibre, low fat and low sodium dietary regimen may have a hypotensive response after a period of 1 month and there is a similar response in both black and white ethnic groups. Further observation of these patients will determine long-term response and compliance.
53名轻度高血压糖尿病患者被分配到高纤维、低脂肪和低钠饮食方案的治疗饮食组或对照组。经过1个月的治疗期后,改良饮食治疗组(n = 35)的平均舒张压显著降低(P < 0.001),同时尿钠排泄显著减少(P < 0.01)。与对照组相比,1个月时舒张压平均值(P < 0.05)和尿钠/钾比值(P < 0.01)也显著降低。白人(n = 16)和西印度裔(n = 10)糖尿病高血压患者对改良饮食表现出类似的显著降压反应(分别为P < 0.05和P < 0.01),尿钠排泄减少。相比之下,亚洲患者没有显著变化。采用高纤维、低脂肪和低钠饮食方案治疗糖尿病患者的高血压,1个月后可能会有降压反应,黑人和白人种族群体的反应相似。对这些患者的进一步观察将确定长期反应和依从性。