Kamada M, Komori A, Chiba S, Nakao T
Scand J Infect Dis. 1983;15(3):227-32. doi: 10.3109/inf.1983.15.issue-3.01.
A prospective study on congenital cytomegalovirus (CMV) infection was carried out in Sapporo, Japan. Only 77 (6.2%) of 1233 pregnant women were seronegative in the first trimester. In such a highly immune population, 11 (0.5%) of 2070 newborn infants were found to have congenital CMV infection. None of them showed any clinical abnormalities during the period of observation (3-24 months), except for a cyst of septum pellucidum in one case. The incidence of congenital CMV infection in the first pregnancies was 1.1% (9/816) and in subsequent pregnancies 0.2% (2/1254). The difference was statistically significant. Three mothers of infants with congenital CMV infection were already seropositive in the first trimester. 26/30 (86.7%) infants, born to mothers with active CMV infection during pregnancy, had started to excrete CMV with urine before the age of 12 months. In contrast, none of the 4 infants born to seronegative mothers excreted CMV.
在日本札幌开展了一项关于先天性巨细胞病毒（CMV）感染的前瞻性研究。1233名孕妇中，仅77名（6.2%）在孕早期血清学检测呈阴性。在这样一个免疫水平较高的人群中，2070名新生儿中有11名（0.5%）被发现患有先天性CMV感染。在观察期（3 - 24个月）内，除1例有透明隔囊肿外，他们均未表现出任何临床异常。初产妇先天性CMV感染的发生率为1.1%（9/816），经产妇为0.2%（2/1254）。差异具有统计学意义。3名先天性CMV感染婴儿的母亲在孕早期血清学检测就已呈阳性。孕期有活动性CMV感染的母亲所生的30名婴儿中有26名（86.7%）在12月龄前开始从尿液中排出CMV。相比之下，血清学检测呈阴性的母亲所生的4名婴儿均未排出CMV。
