Berthelot A, Esposito J
J Am Coll Nutr. 1983;2(4):343-53. doi: 10.1080/07315724.1983.10719931.
The effect of varying the amount of dietary magnesium on the development of hypertension in spontaneously hypertensive (SH) rats was investigated with three diets containing 1.05% (H1Mg diet), 0.52% (H2Mg diet), and 0.008% (LMg diet). The control group was given a diet containing a normal amount of magnesium (0.2%). When the diet was sufficiently supplemented with magnesium (H1Mg diet), the development of hypertension was significantly slowed and the heart rate slightly lowered. With dietary magnesium depletion (LMg diet), the heart rate was accelerated and hypertension developed more rapidly. Excretion of urinary electrolytes (calcium, magnesium, and sodium) was increased by rats fed the H1Mg diet and decreased by rats on the LMg diet. Urinary cAMP was decreased both on the HMg diets and on the LMg diet. With the H1Mg diet, total and ionized calcium and sodium levels in plasma fell, and magnesium plasma levels rose. Rats fed the LMg diet had increased total and ionized calcium and decreased magnesium plasma levels. These results show that dietary magnesium modifies the metabolism of calcium, sodium, magnesium, which can modulate the development of genetic hypertension.
采用含1.05%（高镁饮食H1Mg）、0.52%（中镁饮食H2Mg）和0.008%（低镁饮食LMg）的三种饮食，研究了饮食中镁含量变化对自发性高血压（SH）大鼠高血压发展的影响。对照组给予含正常量镁（0.2%）的饮食。当饮食中镁充分补充时（H1Mg饮食），高血压发展显著减缓，心率略有降低。饮食中镁缺乏时（LMg饮食），心率加快，高血压发展更快。喂食H1Mg饮食的大鼠尿电解质（钙、镁和钠）排泄增加，而喂食LMg饮食的大鼠则减少。高镁饮食和低镁饮食时尿cAMP均降低。采用H1Mg饮食时，血浆中总钙、离子钙和钠水平下降，血浆镁水平上升。喂食LMg饮食的大鼠血浆总钙和离子钙增加，血浆镁水平降低。这些结果表明，饮食中的镁可改变钙、钠、镁的代谢，进而调节遗传性高血压的发展。
