大鼠肝脏微粒体在体外将乙烯转化为环氧乙烷。
Rat liver microsomal transformation of ethene to oxirane in vitro.
作者信息
Schmiedel G, Filser J G, Bolt H M
出版信息
Toxicol Lett. 1983 Dec;19(3):293-7. doi: 10.1016/0378-4274(83)90133-9.
PMID:6318396
Abstract
Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.
摘要
大鼠肝脏微粒体单加氧酶可将乙烯转化为环氧乙烷。与代谢生成乙烯基环氧乙烷的1,3 - 丁二烯相比，这种转化过程进行得更慢。此外，环氧乙烷对测试试剂（对硝基苄基）吡啶的烷基化能力明显低于乙烯基环氧乙烷。这可能表明与丁二烯相比，乙烯的毒性较低。
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