Rat liver microsomal transformation of ethene to oxirane in vitro.
作者信息
Schmiedel G, Filser J G, Bolt H M
出版信息
Toxicol Lett. 1983 Dec;19(3):293-7. doi: 10.1016/0378-4274(83)90133-9.
PMID:6318396
Abstract
Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.
摘要
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