利用塞姆利基森林病毒鉴定人乳中脂质介导的抗病毒活性和抗甲病毒免疫球蛋白A。
Use of Semliki forest virus to identify lipid-mediated antiviral activity and anti-alphavirus immunoglobulin A in human milk.
作者信息
Welsh J K, Skurrie I J, May J T
出版信息
Infect Immun. 1978 Feb;19(2):395-401. doi: 10.1128/iai.19.2.395-401.1978.
Abstract
In a simple and reliable assay system, Semliki forest virus (SFV) was used to detect the activity of antiviral factors in human milk. Fractionation of the milk showed that a heat-stable, lipid-associated activity and an immunoglobulin-associated activity were present, either singly or together, in 85% of the human milk samples tested. Cow and synthetic milk showed neither activity. Extraction of the neutral milk lipids allowed the antiviral to be located with the monoglyceride and free fatty acid fractions. The milk low in antiviral lipids and high in triglycerides also lacked a strong lipase activity. The immunoglobulin anti-SFV activity was shown to be due to immunoglobulin A, the major milk immunoglobulin, and appears to be directed against an alphavirus closely related to SFV, possibly Ross River virus.
摘要
在一个简单可靠的检测系统中，利用辛德毕斯病毒（SFV）检测人乳中抗病毒因子的活性。对乳汁进行分级分离显示，在所检测的85%的人乳样本中，单独或同时存在一种热稳定的、与脂质相关的活性以及一种与免疫球蛋白相关的活性。牛乳和合成乳均未显示出活性。对中性乳脂进行提取后发现，抗病毒物质存在于甘油单酯和游离脂肪酸部分。抗病毒脂质含量低而甘油三酯含量高的乳汁也缺乏较强的脂肪酶活性。已证明，免疫球蛋白抗SFV活性是由主要的乳免疫球蛋白免疫球蛋白A引起的，并且似乎针对的是一种与SFV密切相关的甲病毒，可能是罗斯河病毒。
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