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1
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J Bacteriol. 1984 Feb;157(2):413-9. doi: 10.1128/jb.157.2.413-419.1984.
2
Mutagenesis of the metJBLF gene cluster with transposon Tn5: localization of the metF transcription unit.用转座子Tn5对metJBLF基因簇进行诱变：metF转录单元的定位
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3
Localization of the metJBLF gene cluster of Escherichia coli in lambda met transducing phage.大肠杆菌metJBLF基因簇在λmet转导噬菌体中的定位
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Insertion of bacteriophage lambda into the deo operon of Escherichia coli K-12 and isolation of plaque-forming lambdadeo+ transducing bacteriophages.将噬菌体λ插入大肠杆菌K-12的deo操纵子并分离形成噬菌斑的λdeo⁺转导噬菌体。
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Insertion mutagenesis of the metJBLF gene cluster of Escherichia coli K-12: evidence for an metBL operon.大肠杆菌K-12 metJBLF基因簇的插入诱变：metBL操纵子的证据
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1
Linkage map of Escherichia coli K-12, edition 10: the traditional map.大肠杆菌K-12连锁图谱，第10版：传统图谱。
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Insertion mutagenesis of the metJBLF gene cluster of Escherichia coli K-12: evidence for an metBL operon.大肠杆菌K-12 metJBLF基因簇的插入诱变：metBL操纵子的证据
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4
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6
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7
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8
The Escherichia coli K-12 metJ193 allele contains a point mutation which alters the hydrophobic pocket responsible for in vitro binding of S-adenosylmethionine: effects on cell growth and induction of met regulon expression.大肠杆菌K-12 metJ193等位基因包含一个点突变，该突变改变了负责体外结合S-腺苷甲硫氨酸的疏水口袋：对细胞生长和甲硫氨酸操纵子表达诱导的影响。
J Bacteriol. 1990 Jul;172(7):3918-24. doi: 10.1128/jb.172.7.3918-3924.1990.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Linkage map of Escherichia coli K-12, edition 6.大肠杆菌K-12连锁图谱，第6版。
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Nucleotide sequence of the Q gene and the Q to S intergenic region of bacteriophage lambda.噬菌体λ Q基因及Q到S基因间区域的核苷酸序列。
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4
Nucleotide sequence of the metL gene of Escherichia coli. Its product, the bifunctional aspartokinase ii-homoserine dehydrogenase II, and the bifunctional product of the thrA gene, aspartokinase I-homoserine dehydrogenase I, derive from a common ancestor.大肠杆菌metL基因的核苷酸序列。其产物双功能天冬氨酸激酶II-高丝氨酸脱氢酶II，以及thrA基因的双功能产物天冬氨酸激酶I-高丝氨酸脱氢酶I，源自一个共同的祖先。
J Biol Chem. 1983 Mar 10;258(5):3028-31.
5
Localization of the metJBLF gene cluster of Escherichia coli in lambda met transducing phage.大肠杆菌metJBLF基因簇在λmet转导噬菌体中的定位
Mol Gen Genet. 1982;187(3):401-4. doi: 10.1007/BF00332618.
6
Mutations affecting regulation of methionine biosynthetic genes isolated by use of met-lac fusions.利用met-lac融合技术分离得到的影响甲硫氨酸生物合成基因调控的突变。
J Bacteriol. 1982 Aug;151(2):609-19. doi: 10.1128/jb.151.2.609-619.1982.
7
Structural studies of lambda transducing bacteriophage carrying bacterial deoxyribonucleic acid from the metBJLF region of the Escherichia coli chromosome.携带来自大肠杆菌染色体metBJLF区域细菌脱氧核糖核酸的λ转导噬菌体的结构研究。
J Bacteriol. 1981 Aug;147(2):612-21. doi: 10.1128/jb.147.2.612-621.1981.
8
Plaque assay for lambda transducing phage carrying the E. coli metB gene.携带大肠杆菌metB基因的λ转导噬菌体的噬菌斑测定。
Mol Gen Genet. 1983;190(3):527-30. doi: 10.1007/BF00331087.
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Nucleotide sequence of bacteriophage lambda DNA.噬菌体λDNA的核苷酸序列。
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10
Construction and physical mapping of plasmids containing the metJBLF gene cluster of E. coli K12.含有大肠杆菌K12 metJBLF基因簇的质粒的构建及物理图谱分析
Mol Gen Genet. 1982;187(1):101-6. doi: 10.1007/BF00384390.

大肠杆菌K-12 metJBLF基因簇的metJB组件的物理组织

Physical organization of the metJB component of the Escherichia coli K-12 metJBLF gene cluster.

作者信息

Liljestrand-Golden C A, Johnson J R

出版信息

J Bacteriol. 1984 Feb;157(2):413-9. doi: 10.1128/jb.157.2.413-419.1984.

DOI:10.1128/jb.157.2.413-419.1984
PMID:6319357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC215263/
Abstract

The structures of a series of plaque-forming metJB transducing phage were studied by restriction endonuclease mapping and enzyme activity assay. One of these phage, lambda pmet100, was inactivated by heat shock in the presence of EDTA, and deletion mutants were selected from the survivors. Two of these mutants, lambda pmet100 delta 1 and lambda pmet100 delta 2, were used to confirm the gene order metJ metB when moving clockwise on the linkage map of Escherichia coli K-12. Additional results indicate that the metB gene can be expressed independently of any other component of the met regulon and that the metJ gene also forms a separate transcription unit.

摘要

通过限制性内切酶图谱分析和酶活性测定，对一系列形成噬菌斑的metJB转导噬菌体的结构进行了研究。其中一种噬菌体λpmet100在EDTA存在下经热休克处理后失活，并从存活者中筛选出缺失突变体。利用其中两个突变体λpmet100 delta 1和λpmet100 delta 2，在大肠杆菌K-12的连锁图谱上顺时针移动时，证实了基因顺序为metJ metB。其他结果表明，metB基因可以独立于met调节子的任何其他组分进行表达，并且metJ基因也形成一个单独的转录单元。