Wright J C, Thawley D G, Solorzano R F
Can J Comp Med. 1984 Apr;48(2):184-91.
One month prior to breeding, sows were vaccinated with an attenuated pseudorabies virus vaccine or challenged with a field strain of pseudorabies virus. A third group of sows were not vaccinated or challenged before breeding. Pigs from these sows were vaccinated at 3, 6, or 12 weeks of age and challenged with virulent virus three weeks later. One pig from each litter served as an unvaccinated, unchallenged control. Serum neutralization titers of these pigs were monitored from birth until 22 weeks of age. Titers of the sows were monitored through breeding, gestation and farrowing. The maximum prefarrowing anti-pseudorabies virus titer in the field virus challenged sows occurred four weeks following challenge. A significant decline in titers occurred at farrowing. Titers rose from one week postfarrowing and then declined. Titers in the field virus infected sows were consistently two to threefold greater than those of the vaccinated sows. The maximum prefarrowing anti-pseudorabies virus titer in the vaccinated sows occurred six weeks following vaccination. The geometric mean titer in these sow's then decreased and increased for two weeks after farrowing. The results in the pigs can be summarized as follows: Pigs from control sows had a greater serological response following field virus challenge than following vaccination with a modified live virus. Pigs from control sows responded serologically to vaccination at 3, 6 and 12 weeks of age. Pigs from control sows which were challenged at 6, 9 and 15 weeks of age had similar antibody responses. Pigs from vaccinated sows had no increase in titer following vaccination at three and six weeks of age. Titers increased when these pigs were vaccinated at 12 weeks of age. There was no significant increase in mean titers of pigs from challenged sows following vaccination at 3, 6 and 12 weeks of age. Vaccinated pigs from control and vaccinated sows had a secondary response following challenge three weeks after vaccination.(ABSTRACT TRUNCATED AT 250 WORDS)
配种前一个月，母猪接种了减毒伪狂犬病病毒疫苗或用伪狂犬病病毒野毒株进行攻毒。第三组母猪在配种前未接种疫苗或攻毒。这些母猪所产仔猪在3、6或12周龄时接种疫苗，三周后用强毒病毒进行攻毒。每窝选一头仔猪作为未接种疫苗、未攻毒的对照。从出生到22周龄监测这些仔猪的血清中和效价。监测母猪在配种、妊娠和产仔期间的效价。用野毒株攻毒的母猪在攻毒后四周出现产前抗伪狂犬病病毒效价峰值。产仔时效价显著下降。产后一周效价上升，然后下降。野毒株感染母猪的效价始终比接种疫苗的母猪高两到三倍。接种疫苗的母猪在接种后六周出现产前抗伪狂犬病病毒效价峰值。这些母猪的几何平均效价在产仔后两周下降然后又上升。仔猪的结果总结如下：对照母猪的仔猪在受到野毒株攻毒后的血清学反应比接种改良活病毒疫苗后的反应更强。对照母猪的仔猪在3、6和12周龄时对接种疫苗有血清学反应。6、9和15周龄时受到攻毒的对照母猪的仔猪有相似的抗体反应。接种疫苗的母猪所产仔猪在3和6周龄接种疫苗后效价没有升高。这些仔猪在12周龄接种疫苗时效价升高。3、6和12周龄时攻毒母猪的仔猪接种疫苗后平均效价没有显著升高。来自对照母猪和接种疫苗母猪的接种疫苗仔猪在接种后三周受到攻毒时有二次反应。（摘要截选至250词）
