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从人胎儿软骨分离出的软骨细胞对血浆生长调节素活性的反应。

Response of chondrocytes isolated from human foetal cartilage to plasma somatomedin activity.

作者信息

Ashton I K, Francis M J

出版信息

J Endocrinol. 1978 Mar;76(3):473-7. doi: 10.1677/joe.0.0760473.

DOI:10.1677/joe.0.0760473
PMID:632720
Abstract

Plasma somatomedin activity enhanced the incorporation of [3H]thymidine into chondrocytes isolated from human foetal cartilage during weeks 13-21 of gestation. Human growth hormone (0.1-20 muu./ml), human placental lactogen (0.1-5 microgram/ml) and insulin (0.25-10 muu./ml) had no direct effects on the synthesis of DNA in these chondrocytes, although insulin at concentrations of 2.5-100 mu./ml increased [3H]thymidine incorporation by up to 400%.

摘要

在妊娠13 - 21周期间,血浆生长调节素活性增强了从人胎儿软骨分离出的软骨细胞对[3H]胸苷的掺入。人生长激素(0.1 - 20毫微单位/毫升)、人胎盘催乳素(0.1 - 5微克/毫升)和胰岛素(0.25 - 10毫微单位/毫升)对这些软骨细胞中的DNA合成没有直接影响,尽管浓度为2.5 - 100微单位/毫升的胰岛素可使[3H]胸苷掺入增加高达400%。

相似文献

1
Response of chondrocytes isolated from human foetal cartilage to plasma somatomedin activity.从人胎儿软骨分离出的软骨细胞对血浆生长调节素活性的反应。
J Endocrinol. 1978 Mar;76(3):473-7. doi: 10.1677/joe.0.0760473.
2
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引用本文的文献

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Increased somatomedin and cartilage metabolic activity in rabbit fetuses injected with insulin in utero.子宫内注射胰岛素的兔胎儿中生长介素增加及软骨代谢活性增强。
Diabetologia. 1980 Aug;19(2):143-7. doi: 10.1007/BF00421861.
2
Human fetal cartilage response to plasma somatomedin activity in relation to gestational age.人类胎儿软骨对血浆生长调节素活性的反应与胎龄的关系。
Calcif Tissue Int. 1981;33(3):205-9. doi: 10.1007/BF02409439.
3
Inhibition of growth of the transplantable rat chondrosarcoma by analogs of hypothalamic hormones.下丘脑激素类似物对可移植大鼠软骨肉瘤生长的抑制作用
Proc Natl Acad Sci U S A. 1983 Feb;80(4):1078-82. doi: 10.1073/pnas.80.4.1078.
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Expression of insulin-like growth factor II in human placentas from normal and diabetic pregnancies.胰岛素样生长因子II在正常及糖尿病妊娠孕妇胎盘组织中的表达
Proc Natl Acad Sci U S A. 1986 Dec;83(23):9179-82. doi: 10.1073/pnas.83.23.9179.
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Change in response with age of human articular cartilage to plasma somatomedin activity.人类关节软骨对血浆生长调节素活性的反应随年龄的变化
Calcif Tissue Int. 1979 Nov 26;29(2):89-94. doi: 10.1007/BF02408062.