Rosenberg A M, Hunt D W, Petty R E
J Rheumatol. 1984 Aug;11(4):425-31.
Sera of 153 children with rheumatic diseases were assayed by an enzyme-linked immunosorbent assay (ELISA) for the presence of antibodies to native (n) and to denatured (d) type II collagen (IIC). Among the study population, antibodies to nIIC were detected in 47% with juvenile rheumatoid arthritis (JRA), 21% with spondyloarthropathies, 37% with other rheumatic diseases, 70% with adult onset rheumatoid arthritis (RA), and in less than 1% of nonrheumatic disease control groups. Antibodies to dIIC were detected in 42% of children with JRA, 41% with spondyloarthropathies, 37% of children with other rheumatic diseases, 67% with adult onset RA, and in less than 6% of nonrheumatic disease control groups. These results indicate that, when compared to nonrheumatic disease control groups, antibodies to both nIIC and dIIC occur significantly more frequently in children with a variety of rheumatic diseases.
采用酶联免疫吸附测定法（ELISA）检测了153例风湿性疾病患儿血清中抗天然（n）和变性（d）II型胶原（IIC）抗体的存在情况。在研究人群中，47%的幼年类风湿关节炎（JRA）患儿、21%的脊柱关节病患儿、37%的其他风湿性疾病患儿、70%的成人起病类风湿关节炎（RA）患者检测到抗nIIC抗体，而在非风湿性疾病对照组中，该比例不到1%。42%的JRA患儿、41%的脊柱关节病患儿、37%的其他风湿性疾病患儿、67%的成人起病RA患者检测到抗dIIC抗体，在非风湿性疾病对照组中，该比例不到6%。这些结果表明，与非风湿性疾病对照组相比，各种风湿性疾病患儿中抗nIIC和抗dIIC抗体的出现频率显著更高。
