Santoro R, Lombardi F, Novello F, Amato C, Ruggeri F M, Grandolfo M E, Annesi I, Cortellessa C M, Timperi F, Inglese R
Bull World Health Organ. 1984;62(4):591-5.
A seroepidemiological survey was conducted to assess the effectiveness of the Italian nationwide immunization programme against poliomyelitis. Over 3800 serum samples were collected from persons, aged between 6 months and 79 years and residing in urban and rural areas with different socioeconomic conditions and geographic locations.A very high level of protection was found in the target population, confirming the almost 100% history of complete immunization. Almost all subjects over 30 years of age were found to have poliovirus antibodies, although they had never been vaccinated. In Naples, a higher proportion of subjects susceptible to all 3 types of virus was found in the age group 6-23 months, suggesting a delay in the administration of vaccine. This was confirmed by the analysis of the immunization history. No difference was observed between urban and rural areas, in either serological results or history of immunization.The results confirmed the higher immunogenicity of poliovirus type 2 with respect to the other two types, the effectiveness of the vaccine, and, finally, the efficiency of the operational procedures adopted for its administration.
开展了一项血清流行病学调查，以评估意大利全国脊髓灰质炎免疫规划的有效性。从年龄在6个月至79岁之间、居住在不同社会经济条件和地理位置的城乡地区的人群中收集了3800多份血清样本。在目标人群中发现了很高的保护水平，证实了几乎100%的全程免疫史。几乎所有30岁以上的受试者都被发现有脊髓灰质炎病毒抗体，尽管他们从未接种过疫苗。在那不勒斯，6-23个月年龄组中对所有3种病毒易感的受试者比例较高，表明疫苗接种有所延迟。免疫史分析证实了这一点。在血清学结果或免疫史方面，城乡之间未观察到差异。结果证实了2型脊髓灰质炎病毒相对于其他两种类型具有更高的免疫原性、疫苗的有效性，以及最后，其接种所采用操作程序的效率。
