Hanrahan J P, Benach J L, Coleman J L, Bosler E M, Grabau J C, Morse D L
Yale J Biol Med. 1984 Jul-Aug;57(4):643-50.
During 1982, surveillance identified 207 cases of Lyme disease in New York State. Cases were clustered in two geographic areas, eastern Long Island and northern Westchester counties. Symptoms and signs of Lyme disease in cases were consistent with previous reports, with erythema chronicum migrans (ECM) being the most frequently (77 percent) reported sign of disease. Facial palsy was reported in a surprisingly high 18 percent of cases. Of 160 cases whose sera were submitted for Lyme spirochete specific IgG antibody testing, 112 (70 percent) had titers greater than or equal to 64, while 88 (55 percent) had titers greater than or equal to 128. Positive titers were not associated with any single sign or symptom of disease, but were significantly associated with symptom onset or tick bite occurring during the three-month period of June, July, and August. We conclude that the incidence of Lyme disease in New York is much higher than previously recognized. In addition, our data suggest that a serologic test for Lyme-spirochete IgG antibody lacks sensitivity, but can be useful in confirming the diagnosis of Lyme disease when antibody titers are high.
1982年期间，监测发现纽约州有207例莱姆病病例。病例集中在两个地理区域，即长岛东部和韦斯特切斯特县北部。病例中莱姆病的症状和体征与先前报告一致，慢性游走性红斑（ECM）是最常报告的疾病体征（77%）。令人惊讶的是，18%的病例报告有面神经麻痹。在160例提交莱姆螺旋体特异性IgG抗体检测血清的病例中，112例（70%）滴度大于或等于64，而88例（55%）滴度大于或等于128。阳性滴度与疾病的任何单一体征或症状均无关联，但与6月、7月和8月这三个月期间出现症状或被蜱叮咬显著相关。我们得出结论，纽约州莱姆病的发病率远高于此前的认识。此外，我们的数据表明，莱姆螺旋体IgG抗体的血清学检测缺乏敏感性，但当抗体滴度较高时，可有助于确诊莱姆病。
