Mashimo P A, Yamamoto Y, Slots J, Park B H, Genco R J
J Periodontol. 1983 Jul;54(7):420-30. doi: 10.1902/jop.1983.54.7.420.
These studies demonstrate a unique constellation of organisms populating the subgingival area in periodontitis lesions of patients with juvenile or insulin-dependent diabetes mellitus (IDDM). The cultivable microflora was predominated by Capnocytophaga and anaerobic vibrios in the patients studied. In some patients, Actinobacillus actinomycetemcomitans were also found. This distinguishes the subgingival flora of IDDM patients suffering from periodontitis from that of patients with localized juvenile periodontitis (LJP), and that of adult periodontitis patients. In LJP most patients harbor both A actinomycetemcomitans and Capnocytophaga subgingivally; and in periodontitis lesions from nondiabetic adults, black-pigmented Bacteroides such as B gingivalis or B melaninogenicus subspecies intermedius are often found. Antibiotic susceptibility patterns suggest that penicillin or tetracycline or its analogs such as minocycline may be effective against the predominant cultivable microflora in periodontal lesions of IDDM patients; however, individual patients may harbor flora with significant resistance to these antibiotics.
这些研究表明，在青少年或胰岛素依赖型糖尿病（IDDM）患者的牙周炎病变中，龈下区域存在一组独特的微生物群落。在所研究的患者中，可培养的微生物区系以二氧化碳嗜纤维菌属和厌氧弧菌为主。在一些患者中，还发现了伴放线放线杆菌。这使得患牙周炎的IDDM患者的龈下菌群有别于局限性青少年牙周炎（LJP）患者以及成人牙周炎患者的龈下菌群。在LJP中，大多数患者龈下同时存在伴放线放线杆菌和二氧化碳嗜纤维菌属；而在非糖尿病成人的牙周炎病变中，常可发现产黑色素类杆菌，如牙龈类杆菌或中间型产黑色素类杆菌亚种。抗生素敏感性模式表明，青霉素、四环素或其类似物（如米诺环素）可能对IDDM患者牙周病变中的主要可培养微生物区系有效；然而，个别患者的菌群可能对这些抗生素具有显著抗性。
