Stoll B J, Rowe B, Glass R I, Gross R J, Huq I
J Clin Microbiol. 1983 Oct;18(4):935-7. doi: 10.1128/jcm.18.4.935-937.1983.
The finding that enterotoxigenic (ET) Escherichia coli strains from many geographic areas belong to a limited number of serogroups led investigators to hope that polyvalent antisera could be used to screen for ET E. coli in areas of the world where more complicated tests of toxigenicity are not available. We compared the serotypes of 207 ET E. coli strains obtained from patients attending the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh, in 1980 with results obtained from similar surveys conducted in 1976 and 1978. During that time the distribution of serogroups changed significantly so that only 46% of our strains had O serogroups included in the polyvalent antisera capable of detecting 66% of ET E. coli strains in 1978. O167, a serogroup which was not included previously, was the third most common serogroup in our study. These findings suggest that polyvalent antisera used to screen for ET E. coli need to be reassessed over time as well as in different geographic areas and may not be as useful for field diagnosis as was originally hoped.
许多地理区域的产肠毒素（ET）大肠杆菌菌株属于有限数量的血清群，这一发现使研究人员希望，在世界上无法进行更复杂的产毒检测的地区，可以使用多价抗血清来筛查ET大肠杆菌。我们将1980年从孟加拉国腹泻病研究国际中心达卡医院的患者中分离得到的207株ET大肠杆菌菌株的血清型，与1976年和1978年进行的类似调查结果进行了比较。在此期间，血清群的分布发生了显著变化，以至于我们的菌株中只有46%的O血清群包含在1978年能够检测66%的ET大肠杆菌菌株的多价抗血清中。O167，一个以前未包括的血清群，是我们研究中第三常见的血清群。这些发现表明，用于筛查ET大肠杆菌的多价抗血清需要随着时间的推移以及在不同地理区域进行重新评估，并且可能不像最初希望的那样对现场诊断有用。
