Acara M, Rennick B, LaGraff S, Schroeder E T
Nephron. 1983;35(4):241-3. doi: 10.1159/000183089.
Plasma choline levels were measured in patients who received a kidney transplant, in donors who underwent nephrectomy and in nonrenal surgical patients. Choline was measured using a choline kinase assay. Choline levels in patients receiving a kidney fell from 29.8 +/- 1.86 microM before transplantation to 15.7 +/- 2.32 1 day later; this normal level was maintained for at least 7 months and in a single case for 2 years. Kidney donors and nonrenal surgery patients showed a significant decrease in plasma choline on the day following surgery but choline levels returned to normal by 3 days after surgery. Thus a transplanted functional kidney reduced the high plasma choline levels, associated with uremia, to normal and maintained these normal levels throughout the period of observation.
对接受肾移植的患者、接受肾切除术的供体以及非肾脏手术患者的血浆胆碱水平进行了测量。使用胆碱激酶测定法测量胆碱。接受肾脏移植的患者的胆碱水平在移植前为29.8±1.86微摩尔/升，移植一天后降至15.7±2.32微摩尔/升；这种正常水平维持了至少7个月，在一个病例中维持了2年。肾脏供体和非肾脏手术患者在术后第一天血浆胆碱显著下降，但胆碱水平在术后3天恢复正常。因此，移植的功能性肾脏将与尿毒症相关的高血浆胆碱水平降至正常，并在整个观察期内维持这些正常水平。
