Ugai K, Ishikawa H, Hirohata K, Shirane H
Arthritis Rheum. 1983 Dec;26(12):1434-41. doi: 10.1002/art.1780261204.
When rheumatoid articular cartilage samples were incubated with normal polymorphonuclear leukocytes (PMN) in vitro, large numbers of PMN were seen attached to the articular surface. As observed by electron microscopy, significant numbers of these cells invaded the cartilage tissue and phagocytosed amorphous material which presumably contained immune complexes. In control cartilage from osteoarthritic, pyogenic, and normal subjects, only a few PMN were attached to the articular surface after incubation with PMN. These results demonstrate that immune complexes trapped in the superficial region of the rheumatoid articular cartilage may play an important role in the destruction of cartilage by the release of lysosomal enzymes from PMN.
当类风湿性关节软骨样本在体外与正常多形核白细胞（PMN）一起孵育时，可见大量PMN附着于关节表面。通过电子显微镜观察，大量这些细胞侵入软骨组织并吞噬了可能含有免疫复合物的无定形物质。在骨关节炎、化脓性关节炎患者及正常受试者的对照软骨中，与PMN孵育后，只有少数PMN附着于关节表面。这些结果表明，被困在类风湿性关节软骨表层区域的免疫复合物可能通过PMN释放溶酶体酶在软骨破坏中起重要作用。
