Bille J, Edson R S, Roberts G D
J Clin Microbiol. 1984 Feb;19(2):126-8. doi: 10.1128/jcm.19.2.126-128.1984.
In a comparative fungal blood culture study, a lysis-centrifugation system (Isolator; Du Pont Co., Wilmington, Del.) detected 89% of all episodes of fungemia; the lysis-centrifugation system detected fungemia exclusively or significantly earlier than did a biphasic brain heart infusion bottle system 83% of the time. The lysis-centrifugation system was particularly useful in the early detection of fungemia caused by Candida tropicalis and Candida glabrata. In 53% of the clinically significant episodes, the earlier detection was directly helpful in the management of patients with fungemia. High-magnitude candidemia (greater than 5 CFU/ml of blood) was significantly associated with the presence of an infected intravascular catheter and with Candida species other than Candida albicans. The lysis-centrifugation system was sensitive in the detection of fungemia during the monitoring of patients receiving antifungal agents or after removal of an infected intravascular catheter.
在一项真菌血培养对比研究中，裂解离心系统（伊索莱特；杜邦公司，特拉华州威尔明顿）检测出了89%的真菌血症病例；该裂解离心系统在83%的情况下能单独或比双相脑心浸液瓶系统更早地检测出真菌血症。裂解离心系统在早期检测热带念珠菌和光滑念珠菌引起的真菌血症方面特别有用。在53%具有临床意义的病例中，更早的检测对真菌血症患者的治疗有直接帮助。高菌量念珠菌血症（每毫升血液中念珠菌菌落形成单位大于5个）与感染的血管内导管的存在以及白色念珠菌以外的念珠菌种类显著相关。在监测接受抗真菌药物治疗的患者或拔除感染的血管内导管后，裂解离心系统在检测真菌血症方面很敏感。
