Dewsnup D H, Wright D N
Antimicrob Agents Chemother. 1984 Feb;25(2):165-7. doi: 10.1128/AAC.25.2.165.
Fifty-two clinical isolates of Nocardia asteroides were tested by agar dilution for their susceptibility to 25 antimicrobial agents. In general, susceptibility could not be predicted based on the antibiotic class tested. However, the beta-lactams, including third-generation cephalosporins, were generally ineffective (MIC for 90% of the organisms [MIC90], between 64 and greater than 256 micrograms/ml), whereas minocycline and doxycycline were generally effective (MIC90, 4 and 8 micrograms/ml, respectively). Cycloserine was not effective below 60 micrograms/ml. The MIC50 and MIC90 of sulfamethoxazole was 16 and 32 micrograms/ml, respectively, and that of trimethoprim varied widely (16 and greater than 256 micrograms/ml, respectively). Based on MIC90 data, only doxycycline, minocycline, sulfamethoxazole, and imipenem could be applied empirically.
采用琼脂稀释法对52株星形诺卡菌临床分离株进行了25种抗菌药物的敏感性测试。一般来说，无法根据所测试的抗生素类别预测敏感性。然而，包括第三代头孢菌素在内的β-内酰胺类药物通常无效（90%菌株的最低抑菌浓度[MIC90]在64至大于256微克/毫升之间），而米诺环素和多西环素通常有效（MIC90分别为4和8微克/毫升）。环丝氨酸在低于60微克/毫升时无效。磺胺甲恶唑的MIC50和MIC90分别为16和32微克/毫升，甲氧苄啶的MIC50和MIC90差异很大（分别为16和大于256微克/毫升）。根据MIC90数据，仅多西环素、米诺环素、磺胺甲恶唑和亚胺培南可凭经验应用。
