星形诺卡菌对新型喹诺酮类和β-内酰胺类药物的敏感性
Susceptibility of Nocardia asteroides to new quinolones and beta-lactams.
作者信息
Gombert M E, Aulicino T M, duBouchet L, Berkowitz L R
机构信息
Department of Medicine, State University of New York, Brooklyn 11203.
出版信息
Antimicrob Agents Chemother. 1987 Dec;31(12):2013-4. doi: 10.1128/AAC.31.12.2013.
Abstract
The susceptibility of 31 strains of Nocardia asteroides to various quinolones and beta-lactams, as well as coumermycin, amikacin, and minocycline, was determined by the agar dilution technique. Ciprofloxacin was the most active fluoroquinolone tested on a weight basis, as it inhibited approximately 50% of the isolates at achievable drug levels in serum. Ceftriaxone and cefpirome were the most active cephalosporins in this system with MICs of 8 micrograms/ml for 80% of strains tested. Imipenem, amikacin, and minocycline were the most effective agents tested.
摘要
采用琼脂稀释法测定了31株星形诺卡菌对各种喹诺酮类、β-内酰胺类以及香豆霉素、阿米卡星和米诺环素的敏感性。以重量计，环丙沙星是所测试的活性最高的氟喹诺酮类药物，因为在血清中可达到的药物水平下，它能抑制约50%的分离株。头孢曲松和头孢匹罗是该系统中活性最高的头孢菌素，80%测试菌株的最低抑菌浓度为8微克/毫升。亚胺培南、阿米卡星和米诺环素是所测试的最有效的药物。
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本文引用的文献
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2
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