大鼠肝脏S9组分对硫唑嘌呤在沙门氏菌/哺乳动物微粒体试验中致突变性的影响。
Effect of the rat liver S9 fraction on the mutagenicity of azathioprine in the Salmonella/mammalian microsome assay.
作者信息
Nepomnaschy I, Sommer S E, Nagel R
出版信息
Experientia. 1984 Apr 15;40(4):370-1. doi: 10.1007/BF01952557.
PMID:6370715
Abstract
Azathioprine is a direct acting mutagen in Salmonella typhimurium TA100 and TA1535. Addition of rat liver S9 fraction with or without co-factors, or glutathione, causes a decrease in the mutagenicity of azathioprine in TA100 and an increase in TA1535, indicating the effect of SH groups.
摘要
硫唑嘌呤在鼠伤寒沙门氏菌TA100和TA1535中是一种直接作用的诱变剂。添加有或没有辅助因子的大鼠肝脏S9组分，或谷胱甘肽，会导致硫唑嘌呤在TA100中的诱变性降低，而在TA1535中增加，这表明了巯基的作用。
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