Effect of dietary protein concentration on rat-liver S9 bioactivation of 7,12-dimethylbenz[a]anthracene in the Salmonella/microsome assay.

These studies describe the influence of dietary protein concentration on the ability of rat-liver postmitochondrial fraction (S9) to mediate 7,12-dimethylbenz[a]anthracene (DMBA) mutagenicity in the Ames Salmonella/microsome assay. A negative correlation was observed between dietary protein content and DMBA mutagenicity. The effect of protein was not dependent on the quantity of Aroclor used for induction. Dietary protein did not influence the mutagenicity of DMBA when isolated microsomes were used in place of S9.