Doko F
Jpn J Antibiot. 1984 Dec;37(12):2377-83.
Ceftriaxone (Ro 13-9904, CTRX), a new cephalosporin antibiotic, was basically and clinically studied in the field of obstetrics and gynecology. The following results were obtained. The pelvic dead space exudate and serum levels of CTRX were measured in patients with radical hysterectomy with pelvic lymphadenectomy for uterine cervical cancer after the intravenous injection of 1 g. Immediately after the injection, the serum level increased to 146 micrograms/ml on average and thereafter declined rapidly. The pelvic dead space exudate level attained the peak of 88 micrograms/ml after 4 hours and thereafter declined gradually but was 74 micrograms/ml even at 8 hours after the injection. A total of 13 cases comprising 2 with intrauterine infection, 5 with pelveoperitonitis, 4 with adnexitis and 2 with external genital organ infection were intravenously treated with CTRX at a dose of 1 g twice daily for 3-7 days. The clinical results were good in 12 cases and unknown in 1 case. Eruption was noted in 1 case.
头孢曲松（Ro 13-9904，CTRX），一种新型头孢菌素抗生素，在妇产科领域进行了基础和临床研究。获得了以下结果。在宫颈癌根治性子宫切除术加盆腔淋巴结清扫术患者静脉注射1克后，测量盆腔死腔渗出液和血清中CTRX的水平。注射后立即，血清水平平均升至146微克/毫升，此后迅速下降。盆腔死腔渗出液水平在4小时后达到峰值88微克/毫升，此后逐渐下降，但在注射后8小时仍为74微克/毫升。共有13例患者，其中2例有宫内感染，5例有盆腔腹膜炎，4例有附件炎，2例有外生殖器感染，静脉注射CTRX，剂量为1克，每日两次，持续3至7天。12例临床结果良好，1例情况不明。1例出现皮疹。
