一种单克隆抗DNA抗体也能与细胞表面蛋白结合。
A monoclonal anti-DNA antibody also binds to cell-surface protein(s).
作者信息
Jacob L, Tron F, Bach J F, Louvard D
出版信息
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3843-5. doi: 10.1073/pnas.81.12.3843.
A murine monoclonal anti-DNA antibody ( PME77 ) has been found to bind tightly to the plasma membrane of Raji cells. We show here that this monoclonal anti-DNA antibody reacts in a radioimmunoassay with the cell surface of a variety of mammalian cell types and that the antigenic determinant recognized by the monoclonal anti-DNA antibody at the surface of Raji cells is resistant to DNase. It belongs to polypeptides removed from the cell surface by a mild proteinase K treatment.
已发现一种鼠源单克隆抗DNA抗体（PME77）能紧密结合到Raji细胞的质膜上。我们在此表明，这种单克隆抗DNA抗体在放射免疫测定中能与多种哺乳动物细胞类型的细胞表面发生反应，并且该单克隆抗DNA抗体在Raji细胞表面识别的抗原决定簇对脱氧核糖核酸酶具有抗性。它属于通过温和的蛋白酶K处理从细胞表面去除的多肽。
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