Fray R E, Husain O A, To A C, Watts K C, Lader S, Rogers G T, Taylor-Papadimitriou J, Morris N F
Br J Obstet Gynaecol. 1984 Oct;91(10):1037-41. doi: 10.1111/j.1471-0528.1984.tb03684.x.
This study was designed to determine whether immunohistochemical stains for tumour-associated markers may be useful in the detection and differential diagnosis of premalignant and malignant lesions of the cervix. The expression of four markers detected by monoclonal antibodies, human milk fat globule 1 and 2 (HMFG-1 and 2), Ca1 and anti-carcinoembryonic antigen (anti-CEA) on conventional histological sections of various cervical lesions has been investigated. None of these markers was specific for neoplastic lesions of the cervix and all four markers were expressed by metaplastic as well as neoplastic cells, and it was concluded that their application in the histopathological examination of the cervix is limited.
本研究旨在确定肿瘤相关标志物的免疫组织化学染色是否有助于子宫颈癌前病变和恶性病变的检测及鉴别诊断。研究了通过单克隆抗体检测的四种标志物，即人乳脂肪球1和2（HMFG-1和2）、Ca1和抗癌胚抗原（抗CEA）在各种宫颈病变常规组织切片上的表达情况。这些标志物均对子宫颈肿瘤性病变无特异性，所有四种标志物在化生细胞和肿瘤细胞中均有表达，得出结论：它们在子宫颈组织病理学检查中的应用有限。
