Müller F, Moskophidis M, Prange H W
J Neuroimmunol. 1984 Nov;7(1):43-54. doi: 10.1016/s0165-5728(84)80005-3.
Immunoglobulin M (IgM) antibodies to Treponema pallidum (TP) in serum and cerebrospinal fluid (CSF) can be evaluated quantitatively using a recently introduced enzyme-linked immunosorbent assay (ELISA). In 19 patients with untreated neurosyphilis, local synthesis of TP-specific IgM antibodies within the central nervous system (CNS) was demonstrated by estimation of the CSF/serum ratio of the TP-IgM-ELISA titer/mg total IgM. The TP-specific IgM antibody levels/mg total IgM in the CSF were between 3- and 75-fold higher than those in the corresponding serum of the same patients. Patients with untreated syphilis but without CNS involvement showed equal amounts of TP-specific IgM antibody levels/mg total IgM in CSF and serum, and served as controls.
血清和脑脊液（CSF）中抗梅毒螺旋体（TP）的免疫球蛋白M（IgM）抗体可使用最近推出的酶联免疫吸附测定（ELISA）进行定量评估。在19例未经治疗的神经梅毒患者中，通过估计TP-IgM-ELISA滴度/毫克总IgM的脑脊液/血清比值，证实了中枢神经系统（CNS）内TP特异性IgM抗体的局部合成。脑脊液中TP特异性IgM抗体水平/毫克总IgM比同一患者相应血清中的水平高3至75倍。未经治疗但无CNS受累的梅毒患者脑脊液和血清中TP特异性IgM抗体水平/毫克总IgM相等，并作为对照。
