撒哈拉以南非洲地区恶性疟原虫耐药性问题。
The problem of Plasmodium falciparum drug resistance in Africa south of the Sahara.
作者信息
Onori E
出版信息
Bull World Health Organ. 1984;62 Suppl(Suppl):55-62.
Abstract
The resistance of P. falciparum malaria to dihydrofolate reductase inhibitors, to the 4-aminoquinolines (in particular, chloroquine), and to the combination sulfadoxine-pyrimethamine is reviewed in the light of past and the most recent findings. Considering the gravity of the situation following the recent discovery of resistance of P. falciparum to chloroquine among the semi-immune populations of Africa south of the Sahara, a few suggestions are made for a realistic and rational approach to the drug resistance problem. Some questions that may be worthy of applied field research are briefly mentioned and governments are invited to take the necessary action to ensure better control of the procurement, distribution, and use of antimalarials.
摘要
根据过去和最新的研究结果，对恶性疟原虫对二氢叶酸还原酶抑制剂、4-氨基喹啉类药物（特别是氯喹）以及磺胺多辛-乙胺嘧啶组合的耐药性进行了综述。鉴于最近在撒哈拉以南非洲的半免疫人群中发现恶性疟原虫对氯喹耐药后情况的严重性，针对耐药性问题提出了一些切实可行且合理的应对建议。简要提及了一些可能值得进行应用领域研究的问题，并呼吁各国政府采取必要行动，以确保更好地控制抗疟药物的采购、分发和使用。
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