Gardner D L, Bradley W A, O'Connor P, Orford C R, Brereton J D
Clin Exp Rheumatol. 1984 Jan-Mar;2(1):11-5.
The synovial reaction to the surgical division of an anterior cruciate ligament in inbred beagle dogs, was studied. The left ligaments of 16 animals were divided by a 'blind' technique: the right stifle joints were also explored under aseptic conditions but the cruciate ligaments were not cut. Operation was followed by the formation of a blood-stained sterile effusion and by acute synovitis, sustained on the left, transient on the right. The effusion gradually diminished, becoming serous, but haemosiderin remained within subsynoviocytic macrophages for at least 84 days and lymphocytic foci and synovial cell hyperplasia persisted for similar times. It is suggested that interpretation of the cartilage changes in this cruciate ligament division model of osteoarthrosis should take account of the extent and duration of the post-operative inflammation.
对近亲繁殖的比格犬前交叉韧带手术切断后的滑膜反应进行了研究。16只动物的左侧韧带采用“盲法”技术切断：右侧膝关节也在无菌条件下进行探查，但交叉韧带未切断。手术后，左侧形成血性无菌性积液并伴有急性滑膜炎，右侧则为短暂性。积液逐渐减少，变为浆液性，但含铁血黄素至少在滑膜下巨噬细胞内留存84天，淋巴细胞灶和滑膜细胞增生持续类似时间。提示在该骨关节炎交叉韧带切断模型中对软骨变化的解释应考虑术后炎症的程度和持续时间。
