Gelber R H
Int J Lepr Other Mycobact Dis. 1984 Dec;52(4):471-4.
The dapsone sensitivity of strains of Mycobacterium leprae from 54 multibacilliferous untreated leprosy patients presenting to the United States Public Health Service Hospital in San Francisco, California, U.S.A., from 1978 to 1981 was studied by mouse foot pad inoculation. M. leprae from 53 patients were found fully sensitive to dapsone. M. leprae from one patient were resistant to only the lowest dietary level of dapsone, 0.0001%, since growth of the bacilli was inhibited by higher and clinically easily achievable levels. Mouse plasma dapsone levels confirmed the reliability of the drug-containing diets.
1978年至1981年期间，对来自美国加利福尼亚州旧金山美国公共卫生服务医院的54例未经治疗的多菌型麻风病患者的麻风分枝杆菌菌株进行了氨苯砜敏感性研究，采用小鼠足垫接种法。发现53例患者的麻风分枝杆菌对氨苯砜完全敏感。1例患者的麻风分枝杆菌仅对最低饮食水平的氨苯砜（0.0001%）耐药，因为较高且临床上易于达到的水平可抑制杆菌生长。小鼠血浆氨苯砜水平证实了含药饮食的可靠性。
