van der Kleijn E, Baars A M, Vree T B, van der Dries A
Adv Neurol. 1983;34:421-40.
Pharmacokinetics as the basis for dosage calculation for acute and subacute treatment of status epilepticus have been discussed. Bolus injection and intravenous infusion are the most common forms of drug administration in these cases. Rectal administration may be a good alternative in certain conditions. Intravenous diazepam and phenytoin are the first-line drugs against status epilepticus. Diazepam and sodium valproate have been reported to be effective by the rectal route. Depending on its pharmacokinetic parameters, each drug effect has a different onset, intensity, and time course.
已讨论了作为癫痫持续状态急性和亚急性治疗剂量计算基础的药代动力学。在这些情况下，静脉推注和静脉输注是最常见的给药方式。在某些情况下，直肠给药可能是一种很好的替代方法。静脉注射地西泮和苯妥英钠是治疗癫痫持续状态的一线药物。据报道，地西泮和丙戊酸钠通过直肠途径有效。根据其药代动力学参数，每种药物的作用具有不同的起效时间、强度和时间过程。
