Holle L M, Gidal B E, Collins D M
Division of Pharmacy, MD Anderson Cancer Center, University of Texas, Houston 77030, USA.
Ann Pharmacother. 1995 Oct;29(10):1042-4. doi: 10.1177/106002809502901017.
In patients with intractable status epilepticus who have not responded to therapy with benzodiazepines, phenytoin, and barbiturates, valproate may be a reasonable option. Extemporaneously prepared valproate rectal suppositories or retention enemas have been given in dosages of 200-1200 mg q6h in addition to phenytoin, phenobarbital, or both in adults. The pediatric dose used was 15-20 mg/kg, in addition to phenytoin and/or phenobarbital.
