Medvedev D I, Babichenko I I, Eremina I Z, Kravtsova A I
Biull Eksp Biol Med. 1983 Mar;95(3):108-11.
The effect of alimentary (protein-caloric) deficiency on the brain sensomotor cortex of mice was studied during their postnatal development. It was found that malnutrition of mice from day 10 to day 40 of postnatal period brought about the most remarkable changes in synaptic junctions located on the dendritic spines. They manifested destruction of the spine apparatus, reduction of the width of synaptic slits and of postsynaptic membranes. Dystrophic and destructive alterations are frequently encountered in dendrites, axon terminals, and myelinized axons, indicating the reduced compensatory functions of the CNS.
在小鼠出生后的发育过程中，研究了营养性（蛋白质 - 热量）缺乏对其大脑感觉运动皮层的影响。发现出生后第10天至第40天的小鼠营养不良会导致位于树突棘上的突触连接发生最显著的变化。这些变化表现为棘器的破坏、突触间隙宽度和突触后膜宽度的减小。在树突、轴突终末和髓鞘化轴突中经常出现营养不良和破坏性改变，这表明中枢神经系统的代偿功能降低。
