Scremin O U, Decima E E
J Neurosurg. 1983 May;58(5):742-8. doi: 10.3171/jns.1983.58.5.0742.
Spinal cord blood flow (SCBF) and the effect of end-tidal CO2 concentration (ETCO2) on SCBF (CO2 reactivity) were studied in the lumbar spinal cord of cats by means of the hydrogen-clearance technique Hydrogen gas was administered by inhalation, and its level in spinal cord tissue was estimated amperometrically with small (75 micrometers) platinum electrodes. The average SCBF's at normocapnia (ETCO2 = 4%) of the ventral horn gray matter and of the white matter at several locations were 43.2 and 16.2 ml . 100 gm-1 . min-1, respectively. For gray and white matter, the values of CO2 reactivity, estimated by the coefficient of the regression of SCBF (ml . 100 gm-1 . min-1) on ETCO2 (ml . 100 ml-1) were 11.6 and 2.1, respectively. No differences in SCBF or CO2 reactivity were observed between intact animals kept under N2O-O2 ventilation and decerebrated animals with no anesthesia. After an acute spinal section, ventral horn SCBF and CO2 reactivity (measured eight segments below the cordotomy) were not altered, in spite of the profound neural depression present (that is, spinal shock). Orthodromic (dorsal root) stimulation of the ventral horn neurons induced an average increase in blood flow of 128% above control values. Antidromic (ventral root) motoneuron activation failed to produce any significant changes in ventral horn blood flow.
采用氢清除技术，对猫的腰段脊髓的脊髓血流量（SCBF）以及呼气末二氧化碳浓度（ETCO2）对SCBF的影响（二氧化碳反应性）进行了研究。通过吸入给予氢气，并使用小型（75微米）铂电极以安培法估计脊髓组织中的氢气水平。在正常碳酸血症（ETCO2 = 4%）时，几个部位腹角灰质和白质的平均SCBF分别为43.2和16.2 ml·100 gm-1·min-1。对于灰质和白质，由SCBF（ml·100 gm-1·min-1）对ETCO2（ml·100 ml-1）的回归系数估计的二氧化碳反应性值分别为11.6和2.1。在N2O - O2通气下饲养的完整动物与无麻醉的去大脑动物之间，未观察到SCBF或二氧化碳反应性的差异。急性脊髓横断后，尽管存在深度神经抑制（即脊髓休克），腹角SCBF和二氧化碳反应性（在脊髓切断下方八个节段处测量）并未改变。对腹角神经元进行顺向（背根）刺激可使血流量平均比对照值增加128%。逆向（腹根）运动神经元激活未能使腹角血流量产生任何显著变化。
