人类白细胞对α干扰素诱导剂低反应性与HLA - DR 2的关联。
Association of human leucocyte low responsiveness to inducers of interferon alpha with HLA-DR 2.
作者信息
Abb J, Zander H, Abb H, Albert E, Deinhardt F
出版信息
Immunology. 1983 Jun;49(2):239-44.
The influence of antigens of the major histocompatibility complex (MHC) on the production of interferon (IFN) alpha or IFN gamma by human peripheral blood leucocytes (PBL) in vitro has been studied. Synthesis of IFN gamma by PBL stimulated with purified phytohaemagglutinin (PHA-P) or protein A of Staphylococcus aureus (SpA) appeared not to be controlled by MHC antigens. The production of IFN alpha, however, was influenced by the HLA type of the donor. Low responsiveness of PBL to inducers of IFN alpha (influenza virus, Molt 4 cells) was associated with HLA-DR 2. Implications of these observations for studies of IFN production and natural killer (NK) cell activity are discussed.
已经研究了主要组织相容性复合体（MHC）抗原对人外周血白细胞（PBL）体外产生α干扰素（IFN）或γ干扰素的影响。用纯化的植物血凝素（PHA - P）或金黄色葡萄球菌A蛋白（SpA）刺激的PBL合成γ干扰素似乎不受MHC抗原的控制。然而，α干扰素的产生受供体的HLA类型影响。PBL对α干扰素诱导剂（流感病毒、Molt 4细胞）的低反应性与HLA - DR 2相关。讨论了这些观察结果对干扰素产生研究和自然杀伤（NK）细胞活性的意义。
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