Chiswick M L, Johnson M, Woodhall C, Gowland M, Davies J, Toner N, Sims D G
Br Med J (Clin Res Ed). 1983 Jul 9;287(6385):81-4. doi: 10.1136/bmj.287.6385.81.
Forty four babies, of less than 32 weeks' gestation, were either randomly given 25 mg/kg vitamin E (DL-alpha-tocopherol acetate) intramuscularly after birth (day 0) and on days 1, 2, and 3 or served as controls. Frequent real time ultrasound examinations of the brain were made in each baby during the first week and less frequently thereafter. In babies under 32 weeks' gestation the incidence of intraventricular haemorrhage was lower in supplemented babies (18.8%) compared with the controls (56.3%). On days 0, 1, 2, and 3 median plasma vitamin E concentrations in babies without haemorrhage and in those with subependymal haemorrhage only were similar. Babies with intraventricular haemorrhage had lower median concentrations on day 1 (p less than 0.002) and day 2 (p less than 0.05) compared with those with subependymal haemorrhage and lower concentrations on day 0 (p less than 0.02) and day 1 (p less than 0.05) compared with those without haemorrhage. These findings suggest that in premature babies vitamin E, an antioxidant, protects endothelial cell membranes from oxidative damage and disruption and limits the magnitude of haemorrhage and its spread from the subependyma into the ventricles.
44名孕周小于32周的婴儿，出生后（第0天）及第1、2、3天被随机分为两组，一组肌肉注射25mg/kg维生素E（DL-α-生育酚醋酸酯），另一组作为对照组。在第一周内对每个婴儿进行频繁的脑实时超声检查，之后检查频率降低。在孕周小于32周的婴儿中，补充维生素E的婴儿脑室内出血发生率（18.8%）低于对照组（56.3%）。在第0、1、2、3天，无出血的婴儿和仅发生室管膜下出血的婴儿血浆维生素E浓度中位数相似。与室管膜下出血的婴儿相比，脑室内出血的婴儿在第1天（p<0.002）和第2天（p<0.05）的血浆维生素E浓度中位数较低；与无出血的婴儿相比，脑室内出血的婴儿在第0天（p<0.02）和第1天（p<0.05）的血浆维生素E浓度较低。这些发现表明，对于早产儿，抗氧化剂维生素E可保护内皮细胞膜免受氧化损伤和破坏，并限制出血的程度及其从室管膜下向脑室的扩散。
