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用异源肌动蛋白免疫诱导产生的兔抗肌动蛋白自身抗体；平滑肌抗体产生的一种可能机制。

Rabbit autoantibodies to actin induced by immunization with heterologous actins; a possible mechanism of smooth muscle antibody production.

作者信息

Nishioka M, Watanabe S, Kobayashi K, Nakamura T

出版信息

Clin Exp Immunol. 1983 Jul;53(1):159-64.

PMID:6409475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535545/
Abstract

Antisera against actins from chicken gizzard smooth muscle and ascaris body wall were prepared in rabbits. Immunological cross-reactivity of the antisera with actins of several different species was demonstrated by precipitation reactions in agarose gels and by immunofluorescence studies. The antisera were also reactive with actin of rabbits, the homologous animal used for immunization. The latter finding indicated termination of natural tolerance to actin by immunization of cross-reactive actins. A possible mechanism operating in the induction of smooth muscle antibodies, autoantibodies which have a similar nature to the anti-actin antibody is discussed in relation to the termination of natural tolerance to actin.

摘要

用兔制备了抗鸡砂囊平滑肌肌动蛋白和抗蛔虫体壁肌动蛋白的抗血清。通过琼脂糖凝胶沉淀反应和免疫荧光研究证明了这些抗血清与几种不同物种的肌动蛋白具有免疫交叉反应性。这些抗血清也与用于免疫的同源动物兔的肌动蛋白发生反应。后一发现表明通过交叉反应性肌动蛋白的免疫作用终止了对肌动蛋白的天然耐受性。本文讨论了在诱导平滑肌抗体（一种性质与抗肌动蛋白抗体相似的自身抗体）过程中可能起作用的机制与对肌动蛋白天然耐受性终止之间的关系。

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本文引用的文献

1
The immune response of rabbits tolerant to bovine serum albumin to the injection of other heterologous serum albumins.对牛血清白蛋白产生耐受的兔子对注射其他异种血清白蛋白的免疫反应。
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A binding activity of actin with human C1q.肌动蛋白与人C1q的结合活性。
Biochem Biophys Res Commun. 1982 Oct 15;108(3):1307-12. doi: 10.1016/0006-291x(82)92142-8.
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Immunological differences between actins from cardiac muscle, skeletal muscle, and brain.心肌、骨骼肌和脑肌动蛋白之间的免疫学差异。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2069-73. doi: 10.1073/pnas.77.4.2069.
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The termination of immunological unresponsiveness to bovine serum albumin in rabbits. I. Quantitative and qualitative response to cross-reacting albumins.兔对牛血清白蛋白免疫无反应性的终止。I. 对交叉反应白蛋白的定量和定性反应。
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Autoantibodies and the hepatitis-associated antigen in acute infective hepatitis.急性感染性肝炎中的自身抗体与肝炎相关抗原
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Production of antibody to homologous -fetoprotein in rabbits, rats and horses by immunization with human -fetoprotein.用人甲胎蛋白免疫家兔、大鼠和马以产生抗同源甲胎蛋白的抗体。
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Immunofluorescent tracing of smooth muscle contractile protein antigens in tissues other than smooth muscle.平滑肌收缩蛋白抗原在平滑肌以外组织中的免疫荧光追踪
Clin Exp Immunol. 1974 Jan;16(1):125-35.
9
Reaction of human smooth muscle antibodies with human blood lymphocytes and lymphoid cell lines.人平滑肌抗体与人血淋巴细胞及淋巴样细胞系的反应。
Nature. 1974 Nov 15;252(5480):246-7. doi: 10.1038/252246a0.
10
Indirect immunofluorescence studies of smooth muscle antibodies.平滑肌抗体的间接免疫荧光研究。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Aug;82(4):577-84. doi: 10.1111/j.1699-0463.1974.tb02368.x.

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