Nishioka M, Watanabe S, Kobayashi K, Nakamura T
Clin Exp Immunol. 1983 Jul;53(1):159-64.
Antisera against actins from chicken gizzard smooth muscle and ascaris body wall were prepared in rabbits. Immunological cross-reactivity of the antisera with actins of several different species was demonstrated by precipitation reactions in agarose gels and by immunofluorescence studies. The antisera were also reactive with actin of rabbits, the homologous animal used for immunization. The latter finding indicated termination of natural tolerance to actin by immunization of cross-reactive actins. A possible mechanism operating in the induction of smooth muscle antibodies, autoantibodies which have a similar nature to the anti-actin antibody is discussed in relation to the termination of natural tolerance to actin.
用兔制备了抗鸡砂囊平滑肌肌动蛋白和抗蛔虫体壁肌动蛋白的抗血清。通过琼脂糖凝胶沉淀反应和免疫荧光研究证明了这些抗血清与几种不同物种的肌动蛋白具有免疫交叉反应性。这些抗血清也与用于免疫的同源动物兔的肌动蛋白发生反应。后一发现表明通过交叉反应性肌动蛋白的免疫作用终止了对肌动蛋白的天然耐受性。本文讨论了在诱导平滑肌抗体（一种性质与抗肌动蛋白抗体相似的自身抗体）过程中可能起作用的机制与对肌动蛋白天然耐受性终止之间的关系。
