γ干扰素对由DR和DC基因座控制的HLA II类分子表达的不同影响。
Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci.
作者信息
Ameglio F, Capobianchi M R, Dolei A, Tosi R
出版信息
Infect Immun. 1983 Oct;42(1):122-5. doi: 10.1128/iai.42.1.122-125.1983.
Abstract
Interferon-gamma affected the expression of the products of the immunoassociated antigen complex by a differential modulation of DR- and DC-locus-controlled molecules. In melanoma M14 cells treated with interferon-gamma, levels of DR molecules were increased two- to threefold, whereas levels of DC molecules were increased six- to sevenfold. Similar effects were induced on the two allelic products of each locus.
摘要
干扰素-γ通过对DR和DC位点控制分子的差异调节，影响免疫相关抗原复合物产物的表达。在用干扰素-γ处理的黑色素瘤M14细胞中，DR分子水平增加了两到三倍，而DC分子水平增加了六到七倍。每个位点的两个等位基因产物也诱导了类似的效应。
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