一种单克隆抗DC1抗体可选择性抑制介导特异性细胞溶解活性的效应T细胞的生成。
A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity.
作者信息
Corte G, Moretta A, Cosulich M E, Ramarli D, Bargellesi A
出版信息
J Exp Med. 1982 Nov 1;156(5):1539-44. doi: 10.1084/jem.156.5.1539.
Abstract
The products of the DC locus have been shown to be structurally different from those of the DR locus. In this paper it is shown that, unlike anti-DR antibodies, a monoclonal antibody directed against DC1 does not affect proliferation of T cells in response to alloantigens or soluble antigens or production of Ig in a pokeweed mitogen-stimulated in vitro culture. However, the anti-DC1 inhibits the generation of effector T cells mediating specific cytolytic activity, whereas no inhibitory effect can be observed on natural killer and antibody-dependent cytotoxic cell activities.
摘要
已证明DC基因座的产物在结构上与DR基因座的产物不同。本文表明，与抗DR抗体不同，一种针对DC1的单克隆抗体不会影响T细胞对同种异体抗原或可溶性抗原的增殖反应，也不会影响在体外商陆有丝分裂原刺激培养中Ig的产生。然而，抗DC1抑制介导特异性细胞溶解活性的效应T细胞的产生，而对自然杀伤细胞和抗体依赖性细胞毒性细胞活性未观察到抑制作用。
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本文引用的文献
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Proc Natl Acad Sci U S A. 1981 Jul;78(7):4566-70. doi: 10.1073/pnas.78.7.4566.
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Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.由与HLA - DR基因座紧密连锁的基因座编码的人类Ia抗原的分子鉴定。
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Proc Natl Acad Sci U S A. 1981 Jan;78(1):534-8. doi: 10.1073/pnas.78.1.534.
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