在一个HLA纯合细胞系中存在三种具有不同结构和同种抗原决定簇的Ia物种。
Three Ia species with different structures and alloantigenic determinants in an HLA-homozygous cell line.
作者信息
Tanigaki N, Tosi R, Duquesnoy R J, Ferrara G B
出版信息
J Exp Med. 1983 Jan 1;157(1):231-47. doi: 10.1084/jem.157.1.231.
Abstract
Three distinct molecular subsets with different structures and alloantigenic determinants were identified in human Ia antigens from cells of an HLA-Dw7 homozygous cell line. The subsets carried DR7 specificity, BR4X7 supertypic specificity and MB2 supertypic specificity, respectively, and were immunospecifically separated by the use of operationally monospecific alloantisera. These specificities showed HLA-linked segregation in families and they were distributed in the population according to different but partially overlapping patterns. On peptide mapping analysis, the three subsets showed marked differences in the beta-chains. The alpha-chains of DR7 and BR4X7 subsets were very similar to each other, whereas the alpha-chains of MB2 subset were distinctive from those of DR7 and BR4X7. These data indicate the presence of a minimum of three HLA-linked loci; DR locus, a locus that encodes BR4X7, and a locus that encodes MB2, and substantiate the three-loci concept for the genetic control of human I antigens.
摘要
在来自HLA-Dw7纯合细胞系细胞的人Ia抗原中，鉴定出了具有不同结构和同种异体抗原决定簇的三个不同分子亚群。这些亚群分别携带DR7特异性、BR4X7超型特异性和MB2超型特异性，并通过使用操作上单一特异性的同种异体抗血清进行免疫特异性分离。这些特异性在家族中表现出与HLA相关的分离，并且它们在人群中的分布模式不同但部分重叠。在肽图谱分析中，这三个亚群在β链上表现出明显差异。DR7和BR4X7亚群的α链彼此非常相似，而MB2亚群的α链与DR7和BR4X7的α链不同。这些数据表明至少存在三个与HLA相关的基因座；DR基因座、编码BR4X7的基因座和编码MB2的基因座，并证实了人类I抗原遗传控制的三基因座概念。
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