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蜡螟幼虫中抗铜绿假单胞菌P11 - 1免疫力的转移

Transfer of immunity against Pseudomonas aeruginosa P11-1 in Galleria mellonella larvae.

作者信息

De Verno P J, Aston W P, Chadwick J S

出版信息

Dev Comp Immunol. 1983 Summer;7(3):423-34. doi: 10.1016/0145-305x(83)90027-7.

DOI:10.1016/0145-305x(83)90027-7
PMID:6416902
Abstract

Larvae of Galleria mellonella may be immunized against Pseudomonas aeruginosa by the transfer of whole hemolymph, cell-free hemolymph or hemocytes from insects previously immunized with the lipopolysaccharide of the homologous organisms. Whole immune hemolymph injected as early as 3 hours after vaccination confers protection which persists as long as 40 hours. Hemocytes alone confer good protection when transferred as early as 30 minutes after, and up to about 4 hours after immunization. Transferred protection does not appear to be due to excess immunogen in the hemolymph.

摘要

通过转移来自先前用同源生物体脂多糖免疫过的昆虫的全血淋巴、无细胞血淋巴或血细胞,可以使大蜡螟幼虫对铜绿假单胞菌产生免疫。早在接种疫苗后3小时注射的全免疫血淋巴就能提供长达40小时的保护。血细胞在免疫后30分钟至约4小时内转移时,单独就能提供良好的保护。转移的保护作用似乎不是由于血淋巴中过量的免疫原。

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Transfer of immunity against Pseudomonas aeruginosa P11-1 in Galleria mellonella larvae.蜡螟幼虫中抗铜绿假单胞菌P11 - 1免疫力的转移
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