Pomeroy C, Knodell R G, Swaim W R, Arneson P, Mahowald M L
Gastroenterology. 1984 Jan;86(1):158-61.
Lupus anticoagulant is an immunoglobulin that interferes with prothrombin conversion to thrombin and is manifested biochemically by prolongation of the partial thromboplastin time. Paradoxically, bleeding is rare in association with this anticoagulant, and deep leg vein thromboses, pulmonary emboli, and cerebrovascular accidents have been described in patients with this clotting inhibitor. This report describes the first case of Budd-Chiari syndrome associated with the lupus anticoagulant. The patient presented with abdominal pain and massive ascites. The Budd-Chiari syndrome was confirmed by liver biopsy and venography. No medical condition known to predispose to an increased thrombotic tendency could be identified, and the presence of the lupus anticoagulant in the patient's plasma may provide an explanation for his hypercoagulability and development of the Budd-Chiari syndrome.
狼疮抗凝物是一种干扰凝血酶原转化为凝血酶的免疫球蛋白，其生化表现为部分凝血活酶时间延长。矛盾的是，与这种抗凝物相关的出血很少见，有这种凝血抑制剂的患者曾有深静脉血栓形成、肺栓塞和脑血管意外的报道。本报告描述了首例与狼疮抗凝物相关的布加综合征。该患者表现为腹痛和大量腹水。肝活检和静脉造影证实为布加综合征。未发现已知易导致血栓形成倾向增加的内科疾病，患者血浆中狼疮抗凝物的存在可能为其高凝状态及布加综合征的发生提供了解释。
