瑞典流行性肾病的流行病学调查。

An epidemiological survey of nephropathia epidemica in Sweden.

作者信息

Niklasson B, Nyman L, Linde A, Grandien M, Dalrymple J

出版信息

Scand J Infect Dis. 1983;15(3):239-45. doi: 10.3109/inf.1983.15.issue-3.03.

DOI:10.3109/inf.1983.15.issue-3.03

Abstract

The indirect immunofluorescence test (IFT) using the Hantaan virus (agent of Korean hemorrhagic fever, KHF) was applied for detection of antibodies to nephropathia epidemica (NE). From 103 patients with symptoms suggesting NE, 61% revealed KHF/NE antibodies in the convalescent sera. All seropositive patients seemed to have acquired their disease in NE endemic areas (north of the 60th parallel). Only patients found to have a typical clinical NE (fever, abdominal pain and renal engagement) were seropositive. Antibodies to KHF/NE were found in 4.2% of sera from 647 healthy persons living in NE endemic areas. Signs of local clusters were found. Subclinical or mild disease seems common. Proof of man to man spread of the disease was not found. Sera from 355 persons living outside NE endemic areas were also tested and 2.4% contained KHF/NE antibodies.

摘要

采用汉坦病毒（韩国出血热病原体）进行间接免疫荧光试验（IFT），以检测流行性肾病（NE）抗体。在103例有NE症状的患者中，61%在恢复期血清中显示出韩国出血热/流行性肾病抗体。所有血清阳性患者似乎都是在NE流行地区（北纬60度以北）感染此病的。只有被发现患有典型临床NE（发热、腹痛和肾脏受累）的患者血清呈阳性。在居住于NE流行地区的647名健康人的血清中，4.2%发现有韩国出血热/流行性肾病抗体。发现了局部聚集的迹象。亚临床或轻症疾病似乎很常见。未发现该病人际传播的证据。对居住在NE流行地区以外的355人的血清也进行了检测，2.4%含有韩国出血热/流行性肾病抗体。