血浆中美法仑的高压液相色谱分析
High-pressure liquid chromatographic analysis of melphalan in plasma.
作者信息
Chang S Y, Alberts D S, Melnick L R, Walson P D, Salmon S E
出版信息
J Pharm Sci. 1978 May;67(5):679-82. doi: 10.1002/jps.2600670529.
PMID:641809
Abstract
A new sensitive and rapid high-pressure liquid chromatographic determination of melphalan in plasma was developed. Recovery of 1 microgram added to 1 ml of plasma at 23 degrees was 94% but was greatly reduced at higher temperature. The method has been applied to plasma determinations of melphalan in rats and humans and is currently being utilized for human pharmacokinetic studies.
摘要
已开发出一种用于血浆中马法兰的灵敏、快速的高压液相色谱测定方法。在23摄氏度下，向1毫升血浆中添加1微克马法兰的回收率为94%，但在较高温度下回收率会大幅降低。该方法已应用于大鼠和人体血浆中马法兰的测定，目前正用于人体药代动力学研究。
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