Lawrence P A, Johnston P
Cell. 1984 Mar;36(3):775-82. doi: 10.1016/0092-8674(84)90357-x.
During development of Drosophila the bithorax complex of genes is responsible for diversification of segments in the ectoderm. The muscles derive from the mesoderm and their pattern also varies from segment to segment--a variation that could be determined directly through deployment of the bithorax complex in the muscle cells themselves. Alternatively, the muscle pattern could be determined indirectly, either by the epidermal cells to which the muscles attach, or by the nerves which contact developing muscles. Using a segment-specific muscle found only in males and a new mutation in the bithorax complex, we show that the development of this muscle is independent of the sex and segmental identity of the epidermis. The development of the muscle therefore depends on the sex and state of the bithorax complex in the muscle nuclei themselves or in part of the central nervous system.
在果蝇发育过程中，双胸复合体基因负责外胚层中节段的多样化。肌肉起源于中胚层，其模式也因节段而异——这种变化可能直接由肌肉细胞自身中双胸复合体的部署决定。或者，肌肉模式也可能间接决定，要么由肌肉附着的表皮细胞决定，要么由与发育中的肌肉接触的神经决定。利用仅在雄性果蝇中发现的一种节段特异性肌肉以及双胸复合体中的一个新突变，我们表明这种肌肉的发育独立于表皮的性别和节段身份。因此，这种肌肉的发育取决于肌肉细胞核自身或部分中枢神经系统中双胸复合体的性别和状态。
