LeBlanc O H, Brown J F, klebe J F, Niedrach L W, Slusarczuk G M, Stoddard W H
J Appl Physiol. 1976 Apr;40(4):644-7. doi: 10.1152/jappl.1976.40.4.644.
A new type of pH sensor suitable for chronic intra-vascular implantation by virtue of its small size, flexibility, and ruggedness was constructed and evaluated. The pH-sensitive element was a thin film of an elastromeric polymer made ion permselective to proteons by adding a lipophilic, specific H+-ion carrier. This was coated onto small diameter silver wires to form sensors. In preliminary trials in anesthetized dogs, the sensors permitted continuous, accurate in vivo blood pH measurement with rapid response (less than 0.1 s).
通过其小尺寸、灵活性和坚固性构建并评估了一种适用于慢性血管内植入的新型pH传感器。pH敏感元件是一种弹性体聚合物薄膜，通过添加亲脂性、特异性H⁺离子载体使其对质子具有离子选择透过性。将其涂覆在小直径银线上以形成传感器。在对麻醉犬的初步试验中，这些传感器能够实现连续、准确的体内血液pH测量，且响应迅速（小于0.1秒）。
